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Profiles-Interviews

The Life and Times of a 110 Year-Old Man

The Life and Times of a 110 Year-Old Man

Teaser: 


An Exclusive Interview with Ben Holcomb's Daughter, Leona Ford, in Carnegie, Oklahoma

Ben Holcomb was listed in the Guinness Book of Records as the oldest living person for the year 2000. He was born on July 3rd, 1889 in Robinson, Brown Country, Kansas, to Chestnut Wade Holcomb (1844-1902) and Nancy Sarah Jane Sharp (1848&endash;1920). He was the youngest of eight children and was named for the 23rd President, Benjamin Harrison. His father marched with William Tecumseh Sherman across Georgia in 1864 during the American Civil War. Benjamin Holcomb's family homesteaded in what is now Dewey County, when the Araphaho and Cheyenne lands were opened to settlement.

Q: Are there any other long-lived members in the family?

A: His oldest brother died at 78 of encephalitis. That year there was an outbreak of this disease. His next oldest brother died at 96 years of age. His other brothers and sisters all lived to be over seventy but none of them had a spectacularly long life span.

Q: How is your father's health right now?

A: Daddy is not sick in any fashion right now. He has never had any major diseases; no heart attacks or strokes, although he has been blind in one eye since he was 31.

Q: Can he walk around?

A: He is now in a wheel chair and this is because a nurse insisted that he use a wheel chair when he was 107. He came to the nursing home when he was 105.

Q: What did he do for a living?

A: He farmed all his life, although he also worked as a cook during the Second World War.

Q: Did he smoke or drink? What about his diet?

A: He never smoked or drank at all. My older sister, told me that she thought he drank one or two beers on occasion, but nothing more than this. His family always had milk; they were farmers. When there were a lot of us at home we often had corn-meal mash. We would fry this cornmeal mash and have it for breakfast. He ate a lot of greens and he liked to add vinegar to his greens. He didn't eat much in the way of eggs and he had a special liking for catfish.

Q: How was his mood? His spirit and personality?

A: He has always been in a good humor, full of life. He always had a grin on his face. I have never heard him blame anybody for anything. He has accepted every turn and difficulty he has encountered. He was a farmer and to farm around here means to know hardship. Some years can be very hard. I have a great big photograph of him, the sort of photograph they take at fairs, in the 30s of him leaning over a broken down plow, and there is a caption under the photograph that says that "I am going to keep farming until I lose my last dime". He overcame terrible hardships with his farming. He was conservative when times were good so he still had enough money to live another few years without depending on anybody.

Q: How is his memory?

A: It has gotten slow in the last few years.

Q: Has he taken any medications?

A: Do you know what hydrogene is? He used that for a while. My sister was a nurse and she put him on all sort of medications. But that was my sister. The only medication he takes now is metamucil.

Q: What else do you think might account for his long life? Does anything else come to mind?

A: He liked to keep his weight under control. If he gained a couple of pounds he would cut out cream or sugar or eat less. He didn't do this to please his wife, he did it just for himself. I would also say he enjoyed life. He liked women too.

Q: Longevity is an inherited characteristic. You might have another twenty to thirty years of life ahead of you.

A: If I do I will thank the Lord.

Aging Research--Thoughts on the Present, Future, and Cellular Markers

Aging Research--Thoughts on the Present, Future, and Cellular Markers

Teaser: 


An Interview with Dr. Tomas Prolla

Dr. Tomas A. Prolla, an Assistant Professor at the Departments of Genetics & Medical Genetics of the University of Wisconsin (Madison, USA), shares his thoughts on the field of "cellular markers for aging" and the implications of this research on the future of medicine and our society. Dr. Prolla's research focuses on the age-related changes in gene expression and the extent to which caloric restriction can offset these changes. Last year, Dr. Prolla and Dr. Richard Weindruch published a study identifying several genes involved in aging of mouse skeletal muscle.1 Last March, Dr. Richard Lerner and Dr. Peter Schultz of The Scripps Research Institute (La Jolla, USA) published a study identifying genes involved in aging of human fibroblasts.2

Q: A recent batch of studies has used microarrays to provide a snapshot of the gene changes that occur with aging. These have included your study using mouse skeletal muscle and the recent Scripps study using aging fibroblasts. What is the significance of this work? Have we finally found the much sought after cellular markers for aging? Has this not been one of the Holly Grails of Aging research?

A: "Our findings suggest that DNA microarrays can be used to identify hundreds of biomarkers of aging on a tissue-specific basis.

The Fly That Would Live Forever

The Fly That Would Live Forever

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Investigations into Free Radical Effects on Cells: Interview with Dr. John Phillips at the University of Guelph

Kimby N. Barton, MSc

The contributions that Dr. John Phillips has made to the field of aging research have been mostly serendipitous. Dr. Phillips' major research interest has actually been in the field of what he terms 'oxygen toxicity', which just happens to tie into the free radical theory of aging. The free radical theory of aging states that reactive oxygen species (ROS) cause cellular damage, and that this cellular damage accumulates with time, eventually leading to cellular disease and death.

Dr. Phillips did not always think of oxygen as toxic. In fact, as an undergraduate he shared the popular misconception that oxygen was quite a good thing. It wasn't until he was a graduate student that he attended a seminar in which a researcher announced that he had found a protein called superoxide dismutase or SOD. SOD is an enzyme that helps convert oxygen radicals, into its less toxic form, hydrogen peroxide, which is then, with the help of a second enzyme, catalase, converted into molecular oxygen and water. Phillips was stunned to realize that oxygen was in fact so toxic that an entire system was required to try and prevent the damage it can wreak.

He obtained a faculty position at Guelph, where he began a research program that focussed on the fruit fly, Drosophila melanogaster--a model organism for studying genetic disease.

Mapping the Human Genome, Groundwork for a New Era of Medicine

Mapping the Human Genome, Groundwork for a New Era of Medicine

Teaser: 


Interview with Dr. Jamie Cuticchia, Founder of the Ontario-Based Centre for Bioinformatics Supercomputing

Dr. Jamie Cuticchia is the Head of the Bioinformatics program at the Hospital for Sick Children in Toronto. Since 1997, Dr. Cuticchia has actively and successfully developed this program, which is designed to turn trillions of pieces of biological information into usable knowledge. Dr. Cuticchia kindly agreed to share his thoughts on the future of medicine, bioinformatics, and Canada's role in the overall genome project.

Q: Dr. Cuticchia, we have just seen two rival groups announce that they won the race to sequence the Human Genome. How can they have "won the race", if the complete sequence will not be available until 2003? Who are these two groups? Has the race been "won" and who won it?

A: The "race", which has been heralded by the press for the past year or so, has been between the private effort by Celera Genomics and the public sequencing effort lead by Francis Collins at NIH but including researchers in Europe as well. Celera claims to have the genome sequenced and now is in effect assembling the pieces. This is like saying that they have located all the pieces, but the puzzle still isn't complete. The public effort has gone a more methodical way by sequencing on a clone-by-clone basis, which in effect combines sequencing and assembly.

Simple Studies, Simple Man--Not in the Case of Dr. Salim Yusuf

Simple Studies, Simple Man--Not in the Case of Dr. Salim Yusuf

Teaser: 

Kimby N. Barton, MSc
Assistant Editor,
Geriatrics & Aging

Last year the reports of the HOPE trial were reported in the New England Journal of Medicine, providing evidence for the role of ACE inhibitors in reduction of primary and secondary outcomes of cardiovascular disease. This month we have decided to profile Dr. Salim Yusuf, who was one of the primary researchers involved in this study and is a scientist recognized worldwide for his contributions to the field of cardiovascular research and for his meta-analytic approaches to clinical trials. Geriatrics & Aging was recently afforded an opportunity to ask Dr. Yusuf some questions regarding his contributions to medicine.

Dr. Yusuf began his illustrious career at St. John's Medical College at Bangalore University in India. He was awarded a Rhodes Scholarship, which took him to Oxford where he obtained a Doctorate in Philosophy. He stayed on as a research fellow working with Professors Richard Peto and Peter Sleight. He trained as a cardiologist in Oxford at the Harefield Hospital, and in 1984 moved to the National Institutes of Health as a scientific project officer. At the NIH, he became project officer of several landmark studies and was Chairman of the Working Group on the Clinical Trial on Women's Health. In September of 1992, Dr. Yusuf took up his current positions as Director of the Division of Cardiology at McMaster University, and as Director of the Preventive Cardiology and Therapeutics Program at the Hamilton Civic Hospitals Research Centre.

Dr.

Dr. Carol Sawka: A Leader in Women’s Health Care and Cancer Research

Dr. Carol Sawka: A Leader in Women’s Health Care and Cancer Research

Teaser: 

Jocalyn P. Clark, BSc, MSc

It is an exciting time to be involved in cancer research in Canada and Dr. Carol Sawka is helping lead the way. Over the last fifteen years Dr. Sawka has established an impressive clinical and research career in women's health, focusing on optimizing breast cancer care. Dr. Sawka's leadership roles bridge clinical, research, and policy-making activities, linking scientific research evidence to the development of clinical practice guidelines, and setting the stage for promising new treatments and outcomes for cancer patients.

Like many high profile academic physicians, Dr. Sawka wears several hats. Her eleven year involvement with the Toronto-Sunnybrook Regional Cancer Centre culminated recently in her appointment as Chief Executive Officer. Her career began at the cancer centre in 1988 as a staff oncologist, followed by her appointment in April 1998 as a Division Head. Currently she is also the CEO of the Central East Regional Cancer Centre and a Vice-President of Cancer Care Ontario. In addition, Dr. Sawka is Head of the cancer program at Sunnybrook and Women's College Health Science Centre, as well as an Associate Professor in the Departments of Public Health Sciences and Medicine at the University of Toronto and an Adjunct Senior Scientist at the Institute for Clinical Evaluative Sciences (ICES).

Dr.

Addressing the Health Care Needs of our Rapidly Aging Population

Addressing the Health Care Needs of our Rapidly Aging Population

Teaser: 

Honourable Minister Cam Jackson

Addressing the Health Care Needs of our Rapidly Aging Population
An Interview with the Hon. Cam Jackson, Ontario's Minister of Long-Term Care with Responsibility for Seniors

Olya Lechky

The Honourable Cam Jackson, Ontario's Minister of Long-Term Care with Responsibility for Seniors, has a personal interest in health issues that goes back to his boyhood days in Hamilton, Ontario. Born in this industrial city in February, 1951, of a Ukrainian-Canadian mother and Canadian father, he and his siblings saw firsthand the struggles of their parents to keep a large family healthy. "Raising a family of eight children in the fifties when there was no health insurance, no drug plan, no dental plan was challenging in the absence of this kind of support. I was impressed very early on with the importance of accessibility to health care. In those days, doctors still made house calls. Of course, things have changed tremendously since those days and people face different obstacles in accessing health care services."

After briefly pursuing a career in real estate development in his early twenties, Mr. Jackson decided to follow his true calling of serving the public.

Young People Should Not be Afraid of Aging: Profile of Dr. Serge Gauthier

Young People Should Not be Afraid of Aging: Profile of Dr. Serge Gauthier

Teaser: 

Olya Lechky


Dr. Serge Gouthier

Canada now has the distinction of being in the international forefront of research into the causes and treatment of Alzheimer's Disease (AD). This is due in no small measure to the efforts of Dr. Serge Gauthier and colleagues Drs. Judes Poirier and Rémi Quirion who in 1997 won the prestigious Prix Galien Canada. The award is bestowed annually in recognition of outstanding research contributions in basic science and clinical care.

Dr. Gauthier, director of the Alzheimer's Disease research unit at the McGill Centre for Studies in Aging in Montreal, has been immersed in AD research for over two decades. He has published 175 scientific papers in a host of scientific journals and was the editor of 52 contributions to a textbook called The Clinical Diagnosis and Management of Alzheimer's Disease. "This is the number one textbook on AD in the world right now. So Canada is very much in the forefront in this field.