Karl Farcnik, BSc, MD, FRCPC
Michelle Perskyo, Psy.D, C.Psych
Division of Geriatric Psychiatry,
Toronto Western Hospital
In 1912, Frederic H. Lewy first described a disease associated with the formation of lesions, which are now known to be intracytoplasmic inclusions, in the brains of affected individuals. Evidence now suggests that this disease, Lewy body Dementia (DLB), may be the second most common cause of dementia after Alzheimer's disease (AD).1
In 1980, K. Kosaka described the first clinical case of DLB. However, since a number of different entities associated with Lewy bodies have been described, clinical diagnosis of DLB remains challenging. These entities include diffuse Lewy body disease, cortical Lewy body disease, senile dementia of Lewy type, and a Lewy body variant of Alzheimer's Disease. For this reason, efforts have been made to standardize a single set of criteria to make a diagnosis of DLB. In addition, over the past ten years there has been a concerted effort to better characterize this condition, as well as to focus on aspects of its treatment. This article will review the pathophysiology, diagnostic features, and treatment of DLB.